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KMID : 0378019900330090118
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New Medical Journal
1990 Volume.33 No. 9 p.118 ~ p.126
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A Clinical Study of Efficacy of Sulperazon(Sulbactam/Cefoperazone) in Treatment of Serious Surgical Infections
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Abstract
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A wide range of gram-positive and gram-negative microorganisms can produce betalactamases which are capable of inactivating certain of beta-lactam antibiotics. Sulperazon(Sulbactam plus Cefoperazone) is a newlydeveloped antimicrobial agent. Sulbactam has been combined with Cefoperazone, one of the third-generation cephalosporins, to prevent the destruction of the agent by beta-lactamases, thus increasing its antimicrobial activity against resistent strains.
In this study, 20 cases of serious surgical infections who had been hospitalized to the Department of General Surgery, Pusan National University Hospital, in a period from November, 1989 to June, 1990, were included and assessed both clinically and bacteriologically by the completion of therapy. They were all treated with Sulperazon, 2 to 4 grams per day, at least for a week peri-and post-operatively.
The results obtained were as follows
1. Among the 20 cases, 14 were male and 6 were female. The range of age-distribution was from 25 to 80 in years.
2. There was a variety of underlying surgical diseases requiring various operative procedures, and infections in order of frequency were as follows a. Postoperative wound infection, 6 cases
b. Intra-abdominal abscess, 5 cases
c. Acute cholecystitis and /or cholangitis, 5 cases
d. Pyogenic liver abscess, carbuncle, traumatic wound infection, and subclavian catheter infection, 1 case respectively.
3. Species of pathogens, isolated and cultured from various sources in each clinical case were 5 and they were as follows in order of frequency
a. E. coli from 12 cases >
b. S. aureus from 3 cases
c. Pseud. aeruginosa from 2 cases, and Pseud. maltophilia from l case
d. C. freundii from 1 case
e. Alpha-hemolytic streptococci from 1 case
4. Pathogens were all susceptible to cefoperazone plus sulbactam, but there were some strains resistant to cefoperazone on disc susceptibility testing.
5. By the end of treatment, in 17 cases(85% of all cases) the pathogens were eradicated bacteriologically, and on clinical bases the response was satisfactory and successful in 18 cases(90% of all cases).
6. There wasn´t any clinical or laboratory findings thought to be a side effect of the drug in a maximum period of 2 weeks of administration.
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